Immunological specificity, unique combinations of selected natural globulins provide an alternative to the classical concept

Abstract

The concept of immunological specificity based on a unique combination of natural globulins is an attractive alternative to the classical concept of unique globulin molecules for each possible antigen. Many hitherto separate facets of the antibody response such as antibody diversity, cross-reactions, natural antibodies, increased mitoses in lymphatic tissue, the anamnestic response, and immune tolerance may be related through the general thesis that antibody production is not a unique biological phenomenon but a highly specialized example of certain general cellular processes.