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. 1959 Jun 26;129(3365):1741-2.
doi: 10.1126/science.129.3365.1741.

Bilirubin inhibition of heme biosynthesis

R F LABBE, M R ZASKE, R A ALDRICH

Bilirubin inhibition of heme biosynthesis

R F LABBE et al. Science. .

Abstract

The conversion of protoporphyrin and iron to heme is catalyzed by a soluble enzyme prepared from rat liver. This reaction is inhibited by bilirubin, and initial kinetic studies suggest that the inhibition is due in part to a competition between protoporphyrin and the bile pigment. Implications of this finding in hyperbilirubinemia are mentioned.

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