Exponential amplification of nucleic acids: new diagnostics using DNA polymerases and RNA replicases
- PMID: 1366952
- DOI: 10.1016/0167-7799(91)90189-O
Exponential amplification of nucleic acids: new diagnostics using DNA polymerases and RNA replicases
Abstract
Recent developments in DNA and RNA amplification technology are enabling the design of ultra-sensitive diagnostic assays for infectious diseases. The leading amplification technology is the polymerase chain reaction (PCR). An alternative approach, Q-beta amplification, also promises remarkable speed and precise quantification of assay results.
Similar articles
-
RT-PCR and alternative methods to PCR for in vitro amplification of nucleic acids.Exp Clin Endocrinol Diabetes. 1995;103(3):150-5. doi: 10.1055/s-0029-1211343. Exp Clin Endocrinol Diabetes. 1995. PMID: 7584516 Review.
-
In vitro amplification techniques for the detection of nucleic acids: new tools for the diagnostic laboratory.Yale J Biol Med. 1989 Mar-Apr;62(2):159-71. Yale J Biol Med. 1989. PMID: 2672619 Free PMC article. Review.
-
[Applications of Q beta replicase for diagnostic purposes].Enferm Infecc Microbiol Clin. 1991 Aug-Sep;9(7):391-3. Enferm Infecc Microbiol Clin. 1991. PMID: 1724730 Spanish. No abstract available.
-
Nucleic acid isothermal amplification technologies: a review.Nucleosides Nucleotides Nucleic Acids. 2008 Mar;27(3):224-43. doi: 10.1080/15257770701845204. Nucleosides Nucleotides Nucleic Acids. 2008. PMID: 18260008 Review.
-
Target amplification systems in nucleic acid-based diagnostic approaches.Am Biotechnol Lab. 1990 Oct;8(13):14-25. Am Biotechnol Lab. 1990. PMID: 1370001 Review.
Cited by
-
Advances in nucleic acid-based detection methods.Clin Microbiol Rev. 1992 Oct;5(4):370-86. doi: 10.1128/CMR.5.4.370. Clin Microbiol Rev. 1992. PMID: 1423216 Free PMC article. Review.
-
Inhibition and facilitation of nucleic acid amplification.Appl Environ Microbiol. 1997 Oct;63(10):3741-51. doi: 10.1128/aem.63.10.3741-3751.1997. Appl Environ Microbiol. 1997. PMID: 9327537 Free PMC article. Review. No abstract available.
-
Mixed viral infections: detection and management.Clin Microbiol Rev. 1994 Apr;7(2):143-51. doi: 10.1128/CMR.7.2.143. Clin Microbiol Rev. 1994. PMID: 8055464 Free PMC article. Review.
-
RNA mutagenesis yields highly diverse mRNA libraries for in vitro protein evolution.BMC Biotechnol. 2007 Apr 11;7:18. doi: 10.1186/1472-6750-7-18. BMC Biotechnol. 2007. PMID: 17425805 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical