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Comment
. 2003 Sep 5;114(5):532-3.
doi: 10.1016/s0092-8674(03)00682-2.

Dynamic release of Cdc34 from SCF. the hand that rocks the cradle

Dieter A Wolf  1 , Rory Geyer
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Dynamic release of Cdc34 from SCF. the hand that rocks the cradle

Dieter A Wolf et al. Cell. .
Free article

Abstract

Polyubiquitylation is a complex but poorly understood biochemical reaction catalyzed by E3 ubiquitin ligases. In this issue of Cell, Deffenbaugh et al. provide experimental support for a model in which the dynamic release of the ubiquitin-charged E2 Cdc34 from its primary binding site within the rigid cradle-like SCF E3 complex allows for unexpected spatial flexibility to assemble a polyubiquitin chain.

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