Review
doi: 10.1016/0167-7799(92)90169-v.
Semi-automated solid-phase DNA sequencing
Affiliations
- PMID: 1367934
- DOI: 10.1016/0167-7799(92)90169-v
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Review
Semi-automated solid-phase DNA sequencing
Trends Biotechnol.
1992 Jan-Feb.
Abstract
Increasing the efficiency of DNA sequencing necessitates the development of systems which reduce the need for manual operations by integrating template preparation, sequencing reactions, product separation and detection. A semi-automated system, whereby PCR-amplified biotinylated genomic or plasmid DNA is immobilized on streptavidin-coated magnetic beads, has been developed.
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