Review
doi: 10.1016/0167-7799(92)90178-x.
Phage antibodies: will new 'coliclonal' antibodies replace monoclonal antibodies?
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- PMID: 1367944
- DOI: 10.1016/0167-7799(92)90178-x
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Review
Phage antibodies: will new 'coliclonal' antibodies replace monoclonal antibodies?
Trends Biotechnol.
1992 Mar.
Abstract
Antibodies can now be rapidly isolated from large and diverse recombinant libraries by displaying functional antibody fragments on the surface of bacteriophage particles and directly selecting with antigen. This method has been used to isolate antibodies, including human antibodies, with and without immunization, and to improve the affinity and specificity of antigen binding.
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