Case Reports
doi: 10.1038/sj.jp.7210943.
Tin-mesoporphyrin in the treatment of severe hyperbilirubinemia in a very-low-birth-weight infant
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- PMID: 13679941
- DOI: 10.1038/sj.jp.7210943
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Case Reports
Tin-mesoporphyrin in the treatment of severe hyperbilirubinemia in a very-low-birth-weight infant
J Perinatol.
2003 Sep.
Abstract
Tin-mesoporphyrin (SnMP) is a competitive inhibitor of microsomal heme oxygenase (the rate-limiting enzyme in the heme catabolic pathway). It was administered as a single intramuscular dose at 46 hours of life to a very-low-birth-weight infant with severe hemolytic hyperbilirubinemia who had been awaiting an exchange transfusion. This case documents the effective elimination of the need for an exchange transfusion in a very-low-birth-weight infant and is a confirmation of the experience of others for the use of SnMP in reducing bilirubin production.
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