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Comparative Study
. 1992 Apr;37(1):44-5.
doi: 10.1007/BF00174201.

The effect of Pluronic F-68 on hybridoma cells in continuous culture

M al-Rubeai  1 , A N Emery, S Chalder
Affiliations
Comparative Study

The effect of Pluronic F-68 on hybridoma cells in continuous culture

M al-Rubeai et al. Appl Microbiol Biotechnol. 1992 Apr.

Abstract

The comparative effects of Pluronic on cell growth of hybridomas were studied. The addition of 0.05% Pluronic decreased the steady-state cell number in continuous culture by about 12% compared to a non-supplemented culture. In short-term experiments, results demonstrated a gradual decrease in cell number with increasing concentration of Pluronic. Such growth inhibition was found to be a result of lowering the rate of DNA synthesis.

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