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. 1961 Aug 4;134(3475):343.
doi: 10.1126/science.134.3475.343.

Enzymatic formation of psychotomimetic metabolites from normally occurring compounds

J AXELROD

Enzymatic formation of psychotomimetic metabolites from normally occurring compounds

J AXELROD. Science. .

Abstract

An enzyme has been found that N-methylates serotonin and tryptamine to psychotomimetic metabolites, bufotenine and N,N-dimethyltryptamine. This enzyme is highly localized in the rabbit lung and also N-methylates phenylethylamine derivatives such as tyramine, phenylethylamine , mescaline, and dopamine.

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