Review
doi: 10.1016/0958-1669(92)90086-x.
Protein processing within the secretory pathway
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- PMID: 1368940
- DOI: 10.1016/0958-1669(92)90086-x
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Review
Protein processing within the secretory pathway
Curr Opin Biotechnol.
1992 Oct.
Abstract
Endoproteolytic cleavage of hormone and neuropeptide precursors, as well as many complex proteins, such as coagulation factors and viral glycoproteins, is a key process in the generation of bioactive polypeptides. These cleavages typically occur at the dibasic amino acid residues Lys-Arg or Arg-Arg. The enzymes responsible for the processing belong to a newly discovered family of serine proteases related to the bacterial subtilisins. These include PACE (furin), PC1/PC3, PC2 and PACE4, which have all been characterized functionally and structurally.
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