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. 1992 Oct;56(10):1584-8.
doi: 10.1271/bbb.56.1584.

A novel sulfatase from Pseudomonas testosteroni hydrolyzing lithocholic acid sulfate

Y Tazuke  1 , K Matsuda, S Okada, Y Tsukada
Affiliations
Free article

A novel sulfatase from Pseudomonas testosteroni hydrolyzing lithocholic acid sulfate

Y Tazuke et al. Biosci Biotechnol Biochem. 1992 Oct.
Free article

Abstract

Pseudomonas testosteroni ATCC 11996 was found to produce a novel bile acid sulfate sulfatase that hydrolyzes the sulfate ester bond in lithocholic acid sulfate (LCA-S). The enzyme synthesis was induced by several kinds of bile acids including LCA-S. Mn2+ functioned as an essential component for the enzyme synthesis and SO4(2-) suppressed it. This sulfatase hydrolyzes LCA-S to isolithocholic acid and sulfuric acid with inversion of alpha- to beta-configuration of the hydroxyl group at the third position of lithocholic acid.

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