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Review
. 1992 Dec;3(6):612-22.
doi: 10.1016/0958-1669(92)90005-4.

DNA structure, mutations, and human genetic disease

R R Sinden  1 , R D Wells
Affiliations
Review

DNA structure, mutations, and human genetic disease

R R Sinden et al. Curr Opin Biotechnol. 1992 Dec.

Abstract

The etiology of fragile X syndrome, myotonic dystrophy and Kennedy's disease has been attributed to the massive expansion of triplet repeat DNA sequences. This review details the relationships between the structural diversity of DNA, its secondary structure or DNA-directed mutagenesis, and the expansion of triplet repeats.

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