Review
doi: 10.1016/0958-1669(92)90005-4.
DNA structure, mutations, and human genetic disease
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- PMID: 1369117
- DOI: 10.1016/0958-1669(92)90005-4
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Review
DNA structure, mutations, and human genetic disease
Curr Opin Biotechnol.
1992 Dec.
Abstract
The etiology of fragile X syndrome, myotonic dystrophy and Kennedy's disease has been attributed to the massive expansion of triplet repeat DNA sequences. This review details the relationships between the structural diversity of DNA, its secondary structure or DNA-directed mutagenesis, and the expansion of triplet repeats.
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