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. 1992 Nov;25(5):257-60.
doi: 10.1007/BF01575858.

Role of nalidixic acid in isolation of Salmonella typhimurium strains capable of growth at 48 degrees C

M L Droffner  1 , N Yamamoto
Affiliations

Role of nalidixic acid in isolation of Salmonella typhimurium strains capable of growth at 48 degrees C

M L Droffner et al. Curr Microbiol. 1992 Nov.

Abstract

Salmonella typhimurium thermotolerant mutants dependent on the presence of nalidixic acid for growth at 48 degrees C were isolated and designated nalidixic acid-dependent, thermotolerant mutants, naldttl. Genetic mapping revealed that naldttl alleles map within the gyrA gene. When S. typhimurium strain Q was plated in the dark on nutrient agar containing nalidixic acid (20 micrograms/ml) as a photosensitizer and briefly exposed to white light or near VU light prior to incubation at 42 degrees C, nalidixic acid-resistant mutants arose in about 16 h at frequencies of 5 x 10(-8) for white light and 1 x 10(-6) for near UV light. About 10% of these nalidixic acid-resistant mutants derived from photodynamic mutagenesis exhibited the thermotolerant characteristic.

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