Review
doi: 10.1016/0167-7799(90)90124-g.
Affinity chromatography supports: a look at performance requirements
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- PMID: 1369265
- DOI: 10.1016/0167-7799(90)90124-g
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Review
Affinity chromatography supports: a look at performance requirements
Trends Biotechnol.
1990 Jan.
Abstract
Because of its high selectivity, affinity chromatography is a preferred tool in the downstream processing of high-value proteins and peptides of therapeutic interest. This review examines the affinity supports currently available, and investigates the performance characteristics and properties required of the support matrices for improved affinity-based supports for large-scale purification of biomolecules. Parameters for optimizing an affinity chromatographic process, and the advantages of affinity-based separation for scaled-up systems are highlighted.
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