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Review
. 1990 Jan;8(1):12-6.
doi: 10.1016/0167-7799(90)90124-g.

Affinity chromatography supports: a look at performance requirements

S R Narayanan  1 , L J Crane
Affiliations
Review

Affinity chromatography supports: a look at performance requirements

S R Narayanan et al. Trends Biotechnol. 1990 Jan.

Abstract

Because of its high selectivity, affinity chromatography is a preferred tool in the downstream processing of high-value proteins and peptides of therapeutic interest. This review examines the affinity supports currently available, and investigates the performance characteristics and properties required of the support matrices for improved affinity-based supports for large-scale purification of biomolecules. Parameters for optimizing an affinity chromatographic process, and the advantages of affinity-based separation for scaled-up systems are highlighted.

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