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. 1960 Sep;15(3):412-6.
doi: 10.1111/j.1476-5381.1960.tb01265.x.

A new biological method for the assay of depolarizing substances using the isolated semispinalis muscle of the chick

K J CHILD, E ZAIMIS

A new biological method for the assay of depolarizing substances using the isolated semispinalis muscle of the chick

K J CHILD et al. Br J Pharmacol Chemother. 1960 Sep.

Abstract

The isolated semispinalis cervicis muscle of a 3 to 10 days old chick has been found to provide a very useful assay method for depolarizing substances. There are three main advantages of this preparation over that of the rectus abdominis of the frog: (a) quick relaxation without any artificial stretching of the muscle, (b) greater sensitivity to depolarizing drugs, and (c) no falling off in sensitivity for at least 2 hr.

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References

    1. Pharmacol Rev. 1954 Mar;6(1):53-7 - PubMed
    1. J Physiol. 1942 Jun 2;101(1):115-30 - PubMed

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