Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1961 Apr 1;113(4):713-34.
doi: 10.1084/jem.113.4.713.

The inactivation of enterovirus infectivity by the sulfhydryl reagent p-chloromercuribenzoate

P W CHOPPIN, L PHILIPSON

The inactivation of enterovirus infectivity by the sulfhydryl reagent p-chloromercuribenzoate

P W CHOPPIN et al. J Exp Med. .

Abstract

The infectivity of several enteroviruses was inactivated by the sulfhydryl reagent p-chloromercuribenzoate (PCMB). The rate of inactivation was dependent on the ionic environment in which the reaction was carried out. Inactivation of infectivity was reversed by the thiol compound, reduced glutathione. Under certain conditions, PCMB prevented the adsorption of some enteroviruses to monolayer cultures of monkey kidney cells. The results suggest that enterovirus sulfhydryl groups are involved in the establishment of infection, and that they play a role in the adsorption of virus to host cells.

PubMed Disclaimer

References

    1. J Exp Med. 1959 May 1;109(5):487-504 - PubMed
    1. Proc Soc Exp Biol Med. 1959 Apr;100(4):843-5 - PubMed
    1. J Exp Med. 1959 May 1;109(5):475-85 - PubMed
    1. J Immunol. 1949 Aug;62(4):405-13 - PubMed
    1. Virology. 1956 Aug;2(4):517-31 - PubMed