Review
doi: 10.1016/0167-7799(91)90142-5.
Poliovirus antigen chimeras
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- PMID: 1369352
- DOI: 10.1016/0167-7799(91)90142-5
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Review
Poliovirus antigen chimeras
Trends Biotechnol.
1991 Dec.
Abstract
Poliovirus, the aetiological agent of paralytic poliomyelitis, is arguably the best characterized of all animal viruses. Using recombinant-DNA technology, this information, together with the availability of infectious cDNA clones of the notably safe and efficacious live attenuated Sabin 1 vaccine strains of poliovirus, has enabled the creation of hybrid viruses (chimeras) possessing novel antigenicity. The potential applications of these 'epitope-presentation systems' include their use as immunogens, as antigens for serodiagnosis, and as vaccines.
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