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. 1992 Jun;10(6):679-81.
doi: 10.1038/nbt0692-679.

Functional expression of GABAA chloride channels and benzodiazepine binding sites in baculovirus infected insect cells

D B Carter  1 , D R Thomsen, W B Im, D J Lennon, D M Ngo, W Gale, H K Im, P H Seeburg, M W Smith
Affiliations

Functional expression of GABAA chloride channels and benzodiazepine binding sites in baculovirus infected insect cells

D B Carter et al. Biotechnology (N Y). 1992 Jun.

Abstract

We have employed the baculovirus expression system for the production of insect cell membranes having GABA/benzodiazepine binding sites. Three recombinant baculoviruses each harboring a different GABAA receptor cDNA were introduced into insect cells by simultaneous infection. Infected cells expressed GABA responsive Cl- channels and benzodiazepine binding sites with the same pharmacological specificity as animal cells expressing these receptor subunits.

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