Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1992 Mar;10(3):301-4.
doi: 10.1038/nbt0392-301.

DnaK-mediated alterations in human growth hormone protein inclusion bodies

P Blum  1 , M Velligan, N Lin, A Matin
Affiliations

DnaK-mediated alterations in human growth hormone protein inclusion bodies

P Blum et al. Biotechnology (N Y). 1992 Mar.

Abstract

Protein overproduction in microbes frequently results in protein misfolding and aggregation though the molecular basis for this process is unclear. The HSP70 chaperonin, DnaK, was identified as an important factor controlling heterologous protein aggregation in Escherichia coli. Co-overproduction of DnaK significantly reduced human growth hormone (HGH) protein inclusion body formation and the extent of HGH aggregation.

PubMed Disclaimer

Publication types

LinkOut - more resources