This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features!

Skip to main page content

Add to Collections

Your saved search

Name of saved search:

Search terms:

Test search terms

Would you like email updates of new search results?

Yes
No

Email: (change)

Frequency:

Which day?

Which day?

Report format:

Send at most:

Send even when there aren't any new results

Optional text in email:

Your RSS Feed

. 1992;9(1-3):231-6.

doi: 10.1007/BF02521750.

Process development for the production of recombinant antibodies using the glutamine synthetase (GS) system

M E Brown¹, G Renner, R P Field, T Hassell

Affiliations

PMID: 1369497
DOI: 10.1007/BF02521750

Process development for the production of recombinant antibodies using the glutamine synthetase (GS) system

M E Brown et al. Cytotechnology. 1992.

. 1992;9(1-3):231-6.

doi: 10.1007/BF02521750.

Authors

M E Brown¹, G Renner, R P Field, T Hassell

Affiliation

¹ Celltech Ltd. Slough, Berks, UK.

PMID: 1369497
DOI: 10.1007/BF02521750

No abstract available

PubMed Disclaimer

Similar articles

Attenuated glutamine synthetase as a selection marker in CHO cells to efficiently isolate highly productive stable cells for the production of antibodies and other biologics.
Lin PC, Chan KF, Kiess IA, Tan J, Shahreel W, Wong SY, Song Z. Lin PC, et al. MAbs. 2019 Jul;11(5):965-976. doi: 10.1080/19420862.2019.1612690. Epub 2019 Jun 4. MAbs. 2019. PMID: 31043114 Free PMC article.
Amplification using CHO cell expression vectors.
Kingston RE, Kaufman RJ, Bebbington CR, Rolfe MR. Kingston RE, et al. Curr Protoc Mol Biol. 2002 Nov;Chapter 16:Unit 16.23. doi: 10.1002/0471142727.mb1623s60. Curr Protoc Mol Biol. 2002. PMID: 18265304
Improving the efficiency of CHO cell line generation using glutamine synthetase gene knockout cells.
Fan L, Kadura I, Krebs LE, Hatfield CC, Shaw MM, Frye CC. Fan L, et al. Biotechnol Bioeng. 2012 Apr;109(4):1007-15. doi: 10.1002/bit.24365. Epub 2011 Nov 21. Biotechnol Bioeng. 2012. PMID: 22068567
Molecular genetics of the glutamine synthetases in Rhizobium species.
Espín G, Moreno S, Guzman J. Espín G, et al. Crit Rev Microbiol. 1994;20(2):117-23. doi: 10.3109/10408419409113551. Crit Rev Microbiol. 1994. PMID: 7915906 Review.
The role of glutamine synthetase and glutamate dehydrogenase in nitrogen assimilation and possibilities for improvement in the nitrogen utilization of crops.
Miflin BJ, Habash DZ. Miflin BJ, et al. J Exp Bot. 2002 Apr;53(370):979-87. doi: 10.1093/jexbot/53.370.979. J Exp Bot. 2002. PMID: 11912240 Review.

See all similar articles

Cited by

A human expression system based on HEK293 for the stable production of recombinant erythropoietin.
Chin CL, Goh JB, Srinivasan H, Liu KI, Gowher A, Shanmugam R, Lim HL, Choo M, Tang WQ, Tan AH, Nguyen-Khuong T, Tan MH, Ng SK. Chin CL, et al. Sci Rep. 2019 Nov 14;9(1):16768. doi: 10.1038/s41598-019-53391-z. Sci Rep. 2019. PMID: 31727983 Free PMC article.
Incidence and potential implications of the toxic metabolite methylglyoxal in cell culture: A review.
Chaplen FW. Chaplen FW. Cytotechnology. 1998 May;26(3):173-83. doi: 10.1023/A:1007953628840. Cytotechnology. 1998. PMID: 22358615 Free PMC article.
Comprehensive characterization of glutamine synthetase-mediated selection for the establishment of recombinant CHO cells producing monoclonal antibodies.
Noh SM, Shin S, Lee GM. Noh SM, et al. Sci Rep. 2018 Mar 29;8(1):5361. doi: 10.1038/s41598-018-23720-9. Sci Rep. 2018. PMID: 29599455 Free PMC article.
Screening Strategies for High-Yield Chinese Hamster Ovary Cell Clones.
Yang W, Zhang J, Xiao Y, Li W, Wang T. Yang W, et al. Front Bioeng Biotechnol. 2022 Jun 17;10:858478. doi: 10.3389/fbioe.2022.858478. eCollection 2022. Front Bioeng Biotechnol. 2022. PMID: 35782513 Free PMC article. Review.
Development of Animal-free, Protein-Free and Chemically-Defined Media for NS0 Cell Culture.
Zhang J, Robinson D. Zhang J, et al. Cytotechnology. 2005 Jun;48(1-3):59-74. doi: 10.1007/s10616-005-3563-z. Cytotechnology. 2005. PMID: 19003032 Free PMC article.

See all "Cited by" articles

References

1. Biotechnology (N Y). 1991 Jan;9(1):64-8 - PubMed
1. Biotechnology (N Y). 1990 Jul;8(7):662-7 - PubMed
1. Biotechnology (N Y). 1992 Feb;10(2):169-75 - PubMed
1. J Immunol. 1990 Nov 1;145(9):3011-6 - PubMed
1. Biotechnology (N Y). 1990 May;8(5):421-7 - PubMed

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions

LinkOut - more resources

Other Literature Sources
- The Lens - Patent Citations Database