Review
doi: 10.1016/0168-9525(92)90019-z.
Wilms' tumour: reconciling genetics and biology
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- PMID: 1369730
- DOI: 10.1016/0168-9525(92)90019-z
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Review
Wilms' tumour: reconciling genetics and biology
Trends Genet.
1992 Jan.
Abstract
Wilms' tumour, a paediatric malignancy of the kidney, is a striking example of the relationship between aberrant development and cancer. Several different genetic loci have been implicated in the aetiology of the tumour; genomic imprinting also plays a role. One Wilms' tumour predisposition gene (WT1), encoding a zinc finger protein, is expressed in a limited set of tissues, including developing nephrons and gonads. The biology and genetics of Wilms' tumour underline the developmental relationship between kidneys and gonads.
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