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Review
. 1992 Jan;8(1):16-21.
doi: 10.1016/0168-9525(92)90019-z.

Wilms' tumour: reconciling genetics and biology

V Van Heyningen  1 , N D Hastie
Affiliations
Review

Wilms' tumour: reconciling genetics and biology

V Van Heyningen et al. Trends Genet. 1992 Jan.

Abstract

Wilms' tumour, a paediatric malignancy of the kidney, is a striking example of the relationship between aberrant development and cancer. Several different genetic loci have been implicated in the aetiology of the tumour; genomic imprinting also plays a role. One Wilms' tumour predisposition gene (WT1), encoding a zinc finger protein, is expressed in a limited set of tissues, including developing nephrons and gonads. The biology and genetics of Wilms' tumour underline the developmental relationship between kidneys and gonads.

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