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. 1961 Sep 1;114(3):327-42.
doi: 10.1084/jem.114.3.327.

Studies on infection and immunity in experimental typhoid fever. III. Effect of prophylactic immunization

S GAINES, M LANDY, G EDSALL, A D MANDEL, R J TRAPANI, A S BENENSON

Studies on infection and immunity in experimental typhoid fever. III. Effect of prophylactic immunization

S GAINES et al. J Exp Med. .

Abstract

A study was made of the efficacy of various antityphoid immunizing agents in immunizing chimpanzees against typhoid fever produced by feeding viable S. typhosa. It was found that both acetone-killed and heat-killed, phenol-preserved typhoid vaccines were effective in protecting against infection induced with either homologous or heterologous strains of typhoid bacilli. Purified O antigen induced no discernible protection, but some immunity was afforded by the administration of purified Vi antigen.

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