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. 1992 Jan 15;89(2):471-4.
doi: 10.1073/pnas.89.2.471.

Termination of second messenger signaling in olfaction

I Boekhoff  1 , H Breer
Affiliations

Termination of second messenger signaling in olfaction

I Boekhoff et al. Proc Natl Acad Sci U S A. .

Abstract

By using isolated rat olfactory cilia and a fast kinetics methodology, it has been demonstrated that odorant-induced second messenger signaling in the millisecond time range is terminated via phosphorylation reactions catalyzed by specific protein kinases. The cyclic adenosine nucleotide pathway is turned off by kinase A activity, whereas the inositol trisphosphate cascade is terminated by kinase C. The data support the concept that desensitization of odorant responses involves phosphorylation of key elements in the transduction cascade.

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