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. 1992 Jan 31;182(2):593-9.
doi: 10.1016/0006-291x(92)91774-k.

A role for IGF-1 in the rescue of CNS neurons following hypoxic-ischemic injury

P Gluckman  1 , N Klempt, J Guan, C Mallard, E Sirimanne, M Dragunow, M Klempt, K Singh, C Williams, K Nikolics
Affiliations

A role for IGF-1 in the rescue of CNS neurons following hypoxic-ischemic injury

P Gluckman et al. Biochem Biophys Res Commun. .

Abstract

Three days after unilateral hypoxic-ischemic injury in infant rats insulin-like growth factor 1 (IGF-1) production by astrocytes was enhanced in the injured region. This was associated with increased expression of mRNA for IGF binding protein-3 but not for binding protein-1. In adult rats a single lateral cerebroventricular injection of IGF-1 two hours following a similar injury markedly reduced neuronal loss. It is suggested that endogenous IGF-1 is neurotrophic and that centrally administered IGF-1 may have therapeutic potential for brain injury.

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