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. 1992 Feb;281(2):143-7.
doi: 10.1016/0165-7992(92)90050-r.

Mutagenicity of pyrrolizidine alkaloids in the Salmonella typhimurium/mammalian microsome system

P Rubiolo  1 , L Pieters, M Calomme, C Bicchi, A Vlietinck, D Vanden Berghe
Affiliations

Mutagenicity of pyrrolizidine alkaloids in the Salmonella typhimurium/mammalian microsome system

P Rubiolo et al. Mutat Res. 1992 Feb.

Abstract

The mutagenicity of a series of pyrrolizidine alkaloids, and of extracts from several Italian Senecio species containing pyrrolizidine alkaloids, including S. inaequidens, S. fuchsii and S. cacaliaster, were tested using the Salmonella typhimurium/mammalian microsome system. Retrorsine, senecivernine, seneciphylline and the Senecio extracts showed a weakly mutagenic activity.

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