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. 1992 Jan 15;48(1):8-10.
doi: 10.1007/BF01923594.

An improved thioflavine S method for staining neurofibrillary tangles and senile plaques in Alzheimer's disease

R Guntern  1 , C Bouras, P R Hof, P G Vallet
Affiliations

An improved thioflavine S method for staining neurofibrillary tangles and senile plaques in Alzheimer's disease

R Guntern et al. Experientia. .

Abstract

Large differences are usually observed when standard staining methods for a number of pathological lesions in neurodegenerative disorders are compared. With the modified thioflavine S method presented here (easy and cheap to perform), the morphological appearance of the stained neurofibrillary tangles (NFT) and senile plaques (SP) is greatly improved. Furthermore, the intense contrast between stained lesions and background obtained with this technique permits an accurate automatic quantification of NFT and SP using a computer-assisted image analysis system.

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References

    1. Acta Neuropathol. 1988;77(2):113-9 - PubMed
    1. Arch Neurol. 1985 Nov;42(11):1097-105 - PubMed
    1. Experientia. 1989 Feb 15;45(2):159-61 - PubMed
    1. Neuropathol Appl Neurobiol. 1986 Jan-Feb;12(1):3-9 - PubMed
    1. J Comp Neurol. 1990 Nov 1;301(1):55-64 - PubMed

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