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. 1976 Dec 15;34(3):307-10.
doi: 10.1007/BF00295295.

Mitosis of maternal lymphocytes in the presence of fetal cells: possible implication in prenatal diagnosis from fetal blood samples

J P Chaudhuri, K D Zang

Mitosis of maternal lymphocytes in the presence of fetal cells: possible implication in prenatal diagnosis from fetal blood samples

J P Chaudhuri et al. Hum Genet. .

Abstract

The suppression of proliferation of maternal lymphocytes by the lymphocytes of their own male newborns have been tested in a PHA-induced two-way stimulation system. The mixed lymphocyte cultures of 6 out of 12 such mothers/son pairs had 23--50% metaphases with 46,XX karyotype. In 2 more cases 10% maternal metaphases have been observed. Hence, it appears that fetal lymphocytes are unable to suppress the proliferation of maternal cells completely.

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