doi: 10.1016/0014-5793(92)80172-d.
RNase H activity of HIV reverse transcriptases is confined exclusively to the dimeric forms
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- PMID: 1372272
- DOI: 10.1016/0014-5793(92)80172-d
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RNase H activity of HIV reverse transcriptases is confined exclusively to the dimeric forms
FEBS Lett.
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Free article
Abstract
A method for the rapid preparation of a defined substrate to monitor RNase H activity has been developed. Using this substrate, we have investigated the RNase H activities of the different forms of recombinant HIV-1 and HIV-2 reverse transcriptase (RT) in detail. As we report here, RNase H activity is associated only with the dimeric forms (p51/p66 or p66/p66) of the enzymes.
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