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. 1992 Mar 23;300(1):97-100.
doi: 10.1016/0014-5793(92)80172-d.

RNase H activity of HIV reverse transcriptases is confined exclusively to the dimeric forms

T Restle  1 , B Müller, R S Goody
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Free article

RNase H activity of HIV reverse transcriptases is confined exclusively to the dimeric forms

T Restle et al. FEBS Lett. .
Free article

Abstract

A method for the rapid preparation of a defined substrate to monitor RNase H activity has been developed. Using this substrate, we have investigated the RNase H activities of the different forms of recombinant HIV-1 and HIV-2 reverse transcriptase (RT) in detail. As we report here, RNase H activity is associated only with the dimeric forms (p51/p66 or p66/p66) of the enzymes.

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