doi: 10.7164/antibiotics.45.20.
Protactin, a new antibiotic metabolite and a possible precursor of the actinomycins
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- PMID: 1372309
- DOI: 10.7164/antibiotics.45.20
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Protactin, a new antibiotic metabolite and a possible precursor of the actinomycins
J Antibiot (Tokyo).
1992 Jan.
Free article
Abstract
Streptomyces cucumerosporus strain L703-4 (ATCC 53784) produces a new 4-methyl-3-hydroxyanthraniloylpentapeptide lactone for which we have proposed the name protactin, in addition to several actinomycin components. Protactin is rather resistant to air oxidation but it can be converted to a new actinomycin, actinomycin Zp by ferricyanide oxidation. Actinomycin Zp possesses in vitro antibacterial activity and in vivo antitumor activity against P-388 leukemia in mice.
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