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. 1992 Mar 6;35(5):958-65.
doi: 10.1021/jm00083a023.

Novel benzothiophene-, benzofuran-, and naphthalenecarboxamidotetrazoles as potential antiallergy agents

D T Connor  1 , W A Cetenko, M D Mullican, R J Sorenson, P C Unangst, R J Weikert, R L Adolphson, J A Kennedy, D O Thueson, C D Wright, et al.
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Novel benzothiophene-, benzofuran-, and naphthalenecarboxamidotetrazoles as potential antiallergy agents

D T Connor et al. J Med Chem. .

Abstract

The synthesis and antiallergic activity of a series of novel benzothiophene-, benzofuran-, and naphthalenecarboxamidotetrazoles are described. A number of the compounds inhibit the release of histamine from anti-IgE stimulated basophils obtained from allergic donors. Optimal inhibition is exhibited in benzothiophenes with a 3-alkoxy substituent in combination with a 5-methoxy, 6-methoxy, or a 5,6-dimethoxy group. Compound 13c (CI-959) also inhibited respiratory burst of human neutrophils and the release of mediators from anti-IgE-stimulated human chopped lung.

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