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. 1960 Nov;44(2):327-44.
doi: 10.1085/jgp.44.2.327.

Cat heart muscle in vitro. I. Cell volumes and intracellular concentrations in papillary muscle

E PAGE, A K SOLOMON

Cat heart muscle in vitro. I. Cell volumes and intracellular concentrations in papillary muscle

E PAGE et al. J Gen Physiol. 1960 Nov.

Abstract

Methods have been developed for the simultaneous determination of total water, inulin space, and K and Na content in muscles of 0.5 to 10 mg. wet weight. These methods have been used to define steady state conditions with respect to intracellular K concentration in papillary muscles from cat hearts perfused and contracting isometrically at 27-28 degrees C. and at 37-38 degrees C. Cell volumes and intracellular ionic concentrations have been followed as a function of the external K concentration and compared with values predicted on the basis of electroneutrality and osmotic equilibrium.

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