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. 1992 May;60(5):2110-4.
doi: 10.1128/iai.60.5.2110-2114.1992.

Mapping of functional regions of Clostridium perfringens type A enterotoxin

P C Hanna  1 , E U Wieckowski, T A Mietzner, B A McClane
Affiliations

Mapping of functional regions of Clostridium perfringens type A enterotoxin

P C Hanna et al. Infect Immun. 1992 May.

Abstract

Studies were conducted to allow construction of an initial map of the structure-versus-function relationship of the Clostridium perfringens type A enterotoxin (CPE). Removal of the N-terminal 25 amino acids of CPE increased the primary cytotoxic effect of CPE but did not affect binding. CPE sequences required for at least four epitopes were also identified.

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