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. 1992 Apr 3;256(5053):97-100.
doi: 10.1126/science.1373520.

Molecular cloning of the interleukin-1 beta converting enzyme

D P Cerretti  1 , C J Kozlosky, B Mosley, N Nelson, K Van Ness, T A Greenstreet, C J March, S R Kronheim, T Druck, L A Cannizzaro, et al.
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Molecular cloning of the interleukin-1 beta converting enzyme

D P Cerretti et al. Science. .

Abstract

Interleukin-1 beta (IL-1 beta) mediates a wide range of immune and inflammatory responses. The active cytokine is generated by proteolytic cleavage of an inactive precursor. A complementary DNA encoding a protease that carries out this cleavage has been cloned. Recombinant expression in COS-7 cells enabled the cells to process precursor IL-1 beta to the mature form. Sequence analysis indicated that the enzyme itself may undergo proteolytic processing. The gene encoding the protease was mapped to chromosomal band 11q23, a site frequently involved in rearrangement in human cancers.

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