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. 1992 May;267(1):43-54.
doi: 10.1016/0027-5107(92)90109-f.

Local sequence dependence of rate of base replacement in mammals

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Local sequence dependence of rate of base replacement in mammals

W Bains. Mutat Res. 1992 May.

Abstract

I have analysed the local sequence context of base replacement changes in 78 processed pseudogenes. Transversions occur more often than transitions in a ratio of 3.37 to 1, and G:C is replaced 1.4 times more frequently than A:T. In addition, the bases to the 5' and 3' of the mutating base also influence the rate at which bases change, purine:pyrimidine and pyrimidine:purine pairs changing 1.2 times as fast as purine:purine and pyrimidine:pyrimidine pairs. I discuss implications of this for the mechanism of DNA polymerization in mammals.

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