doi: 10.1126/science.1373910.
Isolation of a complementary DNA that encodes the mammalian splicing factor SC35
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- PMID: 1373910
- DOI: 10.1126/science.1373910
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Isolation of a complementary DNA that encodes the mammalian splicing factor SC35
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Abstract
The mammalian splicing factor SC35 is required for the first step in the splicing reaction and for spliceosome assembly. The cloning and characterization of a complementary DNA encoding this protein revealed that it is a member of a family of splicing factors that includes mammalian SF2/ASF. This family of proteins is characterized by the presence of a ribonucleoprotein (RNP)-type RNA binding motif and a carboxyl-terminal serine-arginine-rich (SR) domain. A search of the DNA sequence database revealed that the thymus-specific exon (ET) of the c-myb proto-oncogene is encoded on the antisense strand of the SC35 gene.
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