Comparative Study
doi: 10.1016/0167-4781(92)90105-9.
Molecular cloning of substance P receptor cDNA from guinea-pig uterus
Affiliations
- PMID: 1374648
- DOI: 10.1016/0167-4781(92)90105-9
Item in Clipboard
Comparative Study
Molecular cloning of substance P receptor cDNA from guinea-pig uterus
Biochim Biophys Acta.
.
Free article
Abstract
A cDNA encoding guinea-pig uterine substance P (SP) receptor has been isolated using the homology screening approach. Northern blot analysis reveals that the corresponding mRNA, of approx. 4.8 kb, is expressed in all tissues tested, but predominantly in the uteri of non-pregnant animals; during pregnancy its expression is reduced. The guinea-pig SP receptor was expressed in COS-7 cells and demonstrated relative ligand affinity in the order: SP much greater than neurokinin A greater than neurokinin B.
Similar articles
-
Molecular cloning of a new bombesin receptor subtype expressed in uterus during pregnancy.Eur J Biochem. 1992 Sep 1;208(2):405-10. doi: 10.1111/j.1432-1033.1992.tb17201.x. Eur J Biochem. 1992. PMID: 1325907
-
Novel selective agonists and antagonists confirm neurokinin NK1 receptors in guinea-pig vas deferens.Br J Pharmacol. 1991 Feb;102(2):511-7. doi: 10.1111/j.1476-5381.1991.tb12202.x. Br J Pharmacol. 1991. PMID: 1707714 Free PMC article.
-
Radioiodinated substance P, neurokinin A, and eledoisin bind predominantly in NK1 receptors in guinea pig lung.Mol Pharmacol. 1992 Jan;41(1):147-53. Mol Pharmacol. 1992. PMID: 1370705
-
Species variants of tachykinin receptor types.Biochem Soc Trans. 1994 Feb;22(1):118-22. doi: 10.1042/bst0220118. Biochem Soc Trans. 1994. PMID: 7515828 Review. No abstract available.
-
Molecular characterization of the three tachykinin receptors.Ann N Y Acad Sci. 1991;632:53-62. doi: 10.1111/j.1749-6632.1991.tb33094.x. Ann N Y Acad Sci. 1991. PMID: 1719912 Review. No abstract available.
Cited by
-
Characterization of NK1 and NK2 tachykinin receptors in guinea-pig and rat bronchopulmonary and vascular systems.Br J Pharmacol. 1994 Mar;111(3):759-68. doi: 10.1111/j.1476-5381.1994.tb14803.x. Br J Pharmacol. 1994. PMID: 7517328 Free PMC article.
-
Using guinea pigs in studies relevant to asthma and COPD.Pulm Pharmacol Ther. 2008 Oct;21(5):702-20. doi: 10.1016/j.pupt.2008.01.004. Epub 2008 Feb 2. Pulm Pharmacol Ther. 2008. PMID: 18462968 Free PMC article. Review.
-
Evidence that tachykinins relax the guinea-pig trachea via nitric oxide release and by stimulation of a septide-insensitive NK1 receptor.Br J Pharmacol. 1996 Mar;117(6):1270-6. doi: 10.1111/j.1476-5381.1996.tb16725.x. Br J Pharmacol. 1996. PMID: 8882625 Free PMC article.
Publication types
MeSH terms
Substances
Associated data
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
LinkOut - more resources
Full Text Sources
Other Literature Sources
