Review
doi: 10.1016/0968-0004(92)90419-a.
Is the multidrug transporter a flippase?
Affiliations
- PMID: 1374941
- DOI: 10.1016/0968-0004(92)90419-a
Item in Clipboard
Review
Is the multidrug transporter a flippase?
Trends Biochem Sci.
1992 Jan.
Abstract
The phenomenon of multidrug resistance is correlated with the presence of a membrane protein, P-glycoprotein, which pumps a wide variety of drugs out of cells thus reducing their toxicity. However, the mechanism of this pumping action remains unclear. In this article, we suggest that several properties of the multidrug transporter may be explained if it acts as a 'flippase' to transport drugs from the inner leaflet of the lipid bilayer to the outer or to the external medium.
Similar articles
-
P-glycoproteins: mediators of multidrug resistance.Semin Cell Biol. 1993 Feb;4(1):63-76. doi: 10.1006/scel.1993.1008. Semin Cell Biol. 1993. PMID: 8095827 Review.
-
Phospholipid flippase activity of the reconstituted P-glycoprotein multidrug transporter.Biochemistry. 2001 Jun 12;40(23):6937-47. doi: 10.1021/bi0024456. Biochemistry. 2001. PMID: 11389609
-
Multidrug resistance: a novel class of membrane-associated transport proteins is identified.Cancer Invest. 1991;9(5):563-9. doi: 10.3109/07357909109018954. Cancer Invest. 1991. PMID: 1682020 Review. No abstract available.
-
The multidrug resistance P-glycoprotein.Curr Opin Cell Biol. 1993 Aug;5(4):684-7. doi: 10.1016/0955-0674(93)90140-l. Curr Opin Cell Biol. 1993. PMID: 7903042 Review.
-
Multidrug resistance due to P-glycoprotein.Hosp Pract (Off Ed). 1990 Apr 15;25(4):67-72, 74, 77. doi: 10.1080/21548331.1990.11703935. Hosp Pract (Off Ed). 1990. PMID: 1969865
Cited by
-
Multiple Molecular Mechanisms to Overcome Multidrug Resistance in Cancer by Natural Secondary Metabolites.Front Pharmacol. 2021 May 21;12:658513. doi: 10.3389/fphar.2021.658513. eCollection 2021. Front Pharmacol. 2021. PMID: 34093189 Free PMC article. Review.
-
Vacuuming the periplasm.J Bacteriol. 2005 Mar;187(6):1879-83. doi: 10.1128/JB.187.6.1879-1883.2005. J Bacteriol. 2005. PMID: 15743933 Free PMC article. Review. No abstract available.
-
MDR1 Ala893 polymorphism is associated with inflammatory bowel disease.Am J Hum Genet. 2003 Dec;73(6):1282-92. doi: 10.1086/379927. Epub 2003 Nov 7. Am J Hum Genet. 2003. PMID: 14610718 Free PMC article.
-
Marine natural products with P-glycoprotein inhibitor properties.Mar Drugs. 2014 Jan 22;12(1):525-46. doi: 10.3390/md12010525. Mar Drugs. 2014. PMID: 24451193 Free PMC article. Review.
-
Permissive linker insertion sites in the outer membrane protein of 987P fimbriae of Escherichia coli.J Bacteriol. 1994 Feb;176(4):1099-110. doi: 10.1128/jb.176.4.1099-1110.1994. J Bacteriol. 1994. PMID: 7906265 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
