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. 1961 Jul 7;134(3471):52-3.
doi: 10.1126/science.134.3471.52.

Inhibiting effect of tobacco smoke on some crystalline enzymes

R LANGE

Inhibiting effect of tobacco smoke on some crystalline enzymes

R LANGE. Science. .

Abstract

Tobacco smoke absorbed in phosphate buffer at neutral pH inhibits irreversibly the enzymes rabbit muscle glyceraldehyde-3-phosphate dehydrogenase and yeast alcohol dehydrogenase, whereas lactic dehydrogenase and glutamic dehydrogenase are not inhibited. A transient inhibition of beef liver catalase occurs. Indirect evidence suggests that the observed enzyme inhibition is caused by peroxides present in the smoke.

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