Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1992 May;76(2):192-208.

In vivo and in vitro interaction of trichloroethylene with macromolecules from various organs of rat and mouse

M Mazzullo  1 , S Bartoli, B Bonora, A Colacci, G Lattanzi, A Niero, P Silingardi, S Grilli
Affiliations
  • PMID: 1376481
Comparative Study

In vivo and in vitro interaction of trichloroethylene with macromolecules from various organs of rat and mouse

M Mazzullo et al. Res Commun Chem Pathol Pharmacol. 1992 May.

Abstract

Trichloroethylene was covalently bound in vivo to DNA, RNA and proteins of rat and mouse organs 22 hr after ip injection. The covalent binding index values of rat and mouse liver DNA classify trichloroethylene as a weak initiator. Labeling of RNA and proteins from various organs of both species was higher than that of DNA. In vitro, trichloroethylene was bioactivated by microsomal fractions dependent on cytochrome P450, mainly from liver of both species, to intermediate(s) capable of binding to exogenous DNA. No particular species-specific difference was evident except for mouse lung microsomes which were more efficient than rat lung microsomes. GSH-transferases capable of bioactivating P450-dependent were present in mouse lung microsomes and in liver microsomes of both species. These data, along those previously reported, provide sufficient evidence for a weak ability of TCY to interact covalently with DNA.

PubMed Disclaimer

Publication types