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Clinical Trial
. 1992 Apr;10(1):43-4.
doi: 10.1007/BF01275480.

Phase II trial of fazarabine (ARA-AC, arabinosyl-5-azacytosine) in metastatic breast cancer

R S Walters  1 , R L Theriault, F A Holmes, G N Hortobagyi, L Esparza
Affiliations
Clinical Trial

Phase II trial of fazarabine (ARA-AC, arabinosyl-5-azacytosine) in metastatic breast cancer

R S Walters et al. Invest New Drugs. 1992 Apr.

Abstract

Fourteen consecutive female patients with metastatic breast cancer received a total of 31 courses of fazarabine at a dose of 2 mg/m2/hour x 72 hours (48 mg/m2/day x 3) as a continuous infusion. There were no responses seen, although one patient achieved stability of her disease for five courses. Because of encouraging in vitro results and the primarily hematologic dose-limiting toxicity, further study in combination with colony stimulating growth factors might be of interest.

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References

    1. Ann Intern Med. 1976 Apr;84(4):389-92 - PubMed
    1. Invest New Drugs. 1987 Dec;5(4):315-28 - PubMed
    1. Biochem Pharmacol. 1977 Dec 15;26(24):2469-72 - PubMed

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