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. 1961 Aug 25;134(3478):557.
doi: 10.1126/science.134.3478.557.

Rapid development of drug-resistant mutants of poliovirus

J L MELNICK, D CROWTHER, J BARRERA-ORO

Rapid development of drug-resistant mutants of poliovirus

J L MELNICK et al. Science. .

Abstract

Guanidine hydrochloride is a potent inhibitor of poliovirus synthesis in cell culture. However, the viral progeny which do grow in the presence of guani-dine may become approximately 10,000 times more resistant to the drug. The phenomenon of drug resistance poses yet another problem in the search for a satisfactory viral chemotherapeutic agent.

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