Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1992 Jun 15;284 ( Pt 3)(Pt 3):649-52.
doi: 10.1042/bj2840649.

Growth hormone activates mitogen-activated protein kinase and S6 kinase and promotes intracellular tyrosine phosphorylation in 3T3-F442A preadipocytes

N G Anderson  1
Affiliations

Growth hormone activates mitogen-activated protein kinase and S6 kinase and promotes intracellular tyrosine phosphorylation in 3T3-F442A preadipocytes

N G Anderson. Biochem J. .

Abstract

Physiological concentrations of growth hormone induced a rapid and transient activation of mitogen-activated protein kinase (MAP kinase) and S6 kinase in 3T3-F442A preadipocytes. These effects were abrogated by staurosporine and in cells chronically pretreated with phorbol esters, suggesting that protein kinase C is involved in the mechanism of activation. In addition, three cytosolic proteins exhibited a growth-hormone-dependent increase in tyrosine phosphorylation.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Endocrinology. 1990 Dec;127(6):3187-95 - PubMed
    1. Mol Endocrinol. 1990 Dec;4(12):2014-20 - PubMed
    1. Proc Natl Acad Sci U S A. 1990 Sep;87(18):7040-4 - PubMed
    1. J Cell Biol. 1988 Apr;106(4):1395-402 - PubMed
    1. Proc Natl Acad Sci U S A. 1989 Sep;86(18):6940-3 - PubMed

MeSH terms