Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1961 Mar;2(1):32-6.
doi: 10.1136/gut.2.1.32.

The histamine test meal in the rat

L S VALBERG, L J WITTS

The histamine test meal in the rat

L S VALBERG et al. Gut. 1961 Mar.

Abstract

A histamine test meal is described for the estimation of the secretion of gastric acid and pepsin in the unanaesthetized intact rat. The stomach of the rat secreted pepsin and a small amount of acid in response to the test meal of hypertonic sucrose. Stimulation with histamine produced a pronounced rise in acid secretion but the output of pepsin remained unchanged. The increase in acid secretion was correlated in the individual rat with a rise in the volume of gastric secretion. Histamine phosphate in a dose of 50 mg./kg. body weight produced maximal stimulation of gastric acid secretion and was free from toxic effects. Choline chloride, in a dose of 126.5 mg./kg. body weight, had no effect on the volume of gastric secretion and it was ineffective as a stimulant of either acid or pepsin secretion.

PubMed Disclaimer

References

    1. Gastroenterology. 1956 Apr;30(4):593-7 - PubMed
    1. Gastroenterology. 1954 Jun;26(6):906-13 - PubMed
    1. Gastroenterology. 1957 Jan;32(1):85-7 - PubMed
    1. J Physiol. 1955 May 27;128(2):35-6P - PubMed
    1. Am J Physiol. 1957 Aug;190(2):221-8 - PubMed

LinkOut - more resources