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. 1992 Jun;15(6):200-1.
doi: 10.1016/0166-2236(92)90033-5.

An 'anatomical cascade hypothesis' for Alzheimer's disease

J Hardy  1
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An 'anatomical cascade hypothesis' for Alzheimer's disease

J Hardy. Trends Neurosci. 1992 Jun.

Abstract

The molecular mechanisms of the cytopathology of Alzheimer's disease are very rapidly being elucidated. However, the factors that restrict the effects of this disease to specific neuroanatomical systems are less well understood. In this brief article a possible hypothesis is outlined to explain this apparent specific localization.

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