doi: 10.7164/antibiotics.29.1328.
Effect of spectinomycin on peptide chain initiation
- PMID: 137888
- DOI: 10.7164/antibiotics.29.1328
Item in Clipboard
Effect of spectinomycin on peptide chain initiation
J Antibiot (Tokyo).
1976 Dec.
Free article
Abstract
Spectinomycin inhibits the formation and causes dissociation of performed specific cell-free initiation complexes prepared with the trinucleotide A-U-G or R17 phage RNA, fmet-RNAF and either 30S ribosomal subunits or 70S ribosomes. Both the initiation factor and the Mg2+-induced processes are subject to inhibition by spectinomycin. The only exception is the Mg2+-induced 70S initiation system formed with A-U-G which is stimulated by spectinomycin.
Similar articles
-
Selective inhibition of initiating ribosomes by spectinomycin.Proc Natl Acad Sci U S A. 1974 May;71(5):1634-8. doi: 10.1073/pnas.71.5.1634. Proc Natl Acad Sci U S A. 1974. PMID: 4275941 Free PMC article.
-
Initiation of protein synthesis. Binding of messenger RNA.J Biol Chem. 1975 Aug 10;250(15):5742-8. J Biol Chem. 1975. PMID: 1097442
-
f2 RNA structure and peptide chain initiation: fMet-tRNA binding directed by methoxyamine-modified unfolded or native-like f2 RNAs.Biochem Biophys Res Commun. 1972 Dec 4;49(5):1272-9. doi: 10.1016/0006-291x(72)90605-5. Biochem Biophys Res Commun. 1972. PMID: 4566675 No abstract available.
-
Active sites in Escherichia coli ribosomes.FEBS Lett. 1974 Mar 23;40(0):suppl:S28-37. FEBS Lett. 1974. PMID: 4604059 Review. No abstract available.
-
Fed-batch bioproduction of spectinomycin.Adv Biochem Eng Biotechnol. 1998;59:1-46. doi: 10.1007/BFb0102295. Adv Biochem Eng Biotechnol. 1998. PMID: 9435459 Review.
Cited by
-
tRNAs as antibiotic targets.Int J Mol Sci. 2014 Dec 25;16(1):321-49. doi: 10.3390/ijms16010321. Int J Mol Sci. 2014. PMID: 25547494 Free PMC article. Review.
-
Lysogenic control of Bacillus subtilis morphology and fitness by Spbetavirus phi3T.Commun Biol. 2025 Aug 18;8(1):1238. doi: 10.1038/s42003-025-08672-x. Commun Biol. 2025. PMID: 40826264 Free PMC article.
-
Derivatives of 4-dihydro-4-deoxy-4(R)-amino spectinomycin and their activity against susceptible and resistant Escherichia coli strains.Antimicrob Agents Chemother. 1982 Jan;21(1):101-6. doi: 10.1128/AAC.21.1.101. Antimicrob Agents Chemother. 1982. PMID: 6282201 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
