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. 1976 Dec;29(12):1328-33.
doi: 10.7164/antibiotics.29.1328.

Effect of spectinomycin on peptide chain initiation

F Reusser
Free article

Effect of spectinomycin on peptide chain initiation

F Reusser. J Antibiot (Tokyo). 1976 Dec.
Free article

Abstract

Spectinomycin inhibits the formation and causes dissociation of performed specific cell-free initiation complexes prepared with the trinucleotide A-U-G or R17 phage RNA, fmet-RNAF and either 30S ribosomal subunits or 70S ribosomes. Both the initiation factor and the Mg2+-induced processes are subject to inhibition by spectinomycin. The only exception is the Mg2+-induced 70S initiation system formed with A-U-G which is stimulated by spectinomycin.

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