doi: 10.1002/jcp.1040890429.
Why do tumor cells have a high aerobic glycolysis?
- PMID: 137907
- DOI: 10.1002/jcp.1040890429
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Why do tumor cells have a high aerobic glycolysis?
J Cell Physiol.
1976 Dec.
Abstract
In Ehrlich ascites cells and several other tumors, the high aerobic glycolysis is maintained by generation of ADP and Pi by the plasma membrane Na+K+ ATPase. The high ATP activity is caused by a defective pump that operates at a low efficiency. Studies of the mechanism of action of the Na+K+ ATPase and other pump ATPases suggest several alternative mechanisms that might account for the decreased efficiency. The possibility of involvement of a proteolipid is under investigation.
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